ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
Solid lipid nanoparticles (SLNs) are a new and innovative therapeutic delivery system for administering molecules into the brain. Brain is the most delicate organ in the body and drugs accessing to the brain is severely limited by some of the factors such as the blood-brain barrier (BBB), P-gp efflux mechanism etc. SLNs are tiny colloidal carriers composed of biocompatible/biodegradable lipid matrix that is solid at body temperature and exhibit size range in between 100-400nm. All excipients are of GRAS (Generally Recognized As Safe) substances or accepted GRAS status, where a wide variety of substances can be used for formulating purposes This review highlights about the advantages of SLN over other colloidal carriers as well as the advantages of nanoparticle for brain targeting, some proposed mechanisms to cross the BBB, incorporation models and release of the drugs from SLN.



Key words:
Solid lipid nanoparticles (SLNs); mechanism of nanoparticles to cross BBB; coating of SLN; drug incorporation model; release of SLN after incorporation.

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June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No30
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 25 / Review Article

BRAIN DELIVERY BY SOLID LIPID NANOPARTICLES FOR CNS DRUGS

Lireni. C. Humtsoe1*, N. Jawahar1,
K. Gowthamarajan1,
S. N. Meyyanathan1, Sumeet Sood1

1Department of pharmaceutics,
JSS College of pharmacy,Ooty, Tamilnadu, India
Email:lenny_hmt@yahoo.com
Lireni C. H.
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