ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 24
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 24 / Review Article


A REVIEW ON DIFFERENT ACTIVITY OF QUINOLONE DERIVATIVES


Singh Smita*,Gaurav Anand,
Singh Ranjit, Verma Vikrant


1
Laboratory of pharmaceutical sciences
Shobhit University, Meerut U.P., India

Email:
smita0082@gmail.com
Smita Singh
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ABSTRACT
  
 
Nalidixic acid is considered to be the predecessor of all members of the quinolone family, including the first, second, third and fourth generations. Aim was exploring effective compounds with better anticonvulsant activity and lower neurotoxicity; compounds were designed and synthesized, by substituting triazone with triazolo as in compound II. The hypothesis was that triazone compounds may have higher affinity to the receptor due to the carbonyl group, and thus may increase the anticonvulsant activity. The introduction of alkoxy group to the 7th position of 1, 2, 4-triazole quinoline remarkably increased their anticonvulsant activity. So, synthesis of a series of 8-alkoxy-5, 6-dihydro-[1, 2, 4] triazino [4, 3- a] quinolin-1-one derivatives was done to discuss the influence of the 8-alkoxy on anticonvulsant activity; and found derivative as most active compound.


Key words:
 
Nalidixic acid, anticonvulsant activity, quinolone family.