Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
The present study was aimed at investigating the hepatoprotective activity of the Ethanolic extract of Acacia concinna Pods(Fabaceae) against carbon tetrachloride induced hepatotoxicity in rats. Liver function was assessed by then determination of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGOT), alkaline phosphatase (ALP), Total billurbin and direct billurubin. Histopathological studies revealed that concurrent administration of the extract with carbon tetrachloride exhibited protective of the liver, which further evidenced its hepatoprotective activity. The result suggest that the use of Ethanolic extract of Acacia concinna Pods exhibited significant protective from liver damage in CC14 induced liver damage model. Phytochemical screening of this plant revealed the presence flavanoids, saponins, terpenoids and tannis.
Key words: Acacia concinna , Carbon Tetrachloride, Hepatotoxicity .
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 23
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 23 / Research Article
HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF PODS OF ACACIA CONCINNA
Kumar tataji.Setti*1, Ramakrishnan. G1,
K. R, Jaykar. B1, Vijaya Kumar.Dadi1
11Department of Pharmacology ,
Vinayaka Missionís College of Pharmacy,
Yercaud Main Road, Salem-636008, Tamilnadu, India.
Kumar T. S.