ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
The objective of the present study was to develop the membrane controlled transdermal systems of glipizide and to evaluate with respect to various in vitro parameters. The membrane moderated transdermal systems were prepared using drug containing carbopol gel as reservoir and Eudragit RS-100(ERL), Eudragit RL-100(ERS) and Poly(ethylene-co-vinyl acetate (EVA) (18% vinyl acetate content) rate controlling membranes. The membrane was prepared by solvent evaporation mercury subtract method. The systems were evaluated for various in vitro parameters (Thickness, Folding endurance, Water Vapor Transmission rate, In vitro Drug permeation). Variations in permeation profiles among the formulations containing different rate controlling membranes were observed. The present study shows that membrane controlled transdermal systems of glipizide exhibited better in vitro release.


Key words:
 
Transdermal drug delivery; Membrane controlled Patch; Glipizide; Eudragit RL 100;Eudragit RS 100; EVA; In vitro permeation studies.


June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 19
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 19 / Research Article

DEVELOPMENT OF A MEMBRANE-CONTROLLED TRANSDERMAL THERAPEUTICSYSTEM CONTAINING GLIPIZIDE

Shankar. S. J1,2*
, Varalakshmi. C2 ,
Raken Patel1, Manoj. K1

1Department of pharmaceutics,
P.E.S College of Pharmacy, Bangalore.
2Department of Chemistry,
School of Advanced Studies, VIT University, Vellore.
Email:shankarsj@rediffmail.com
Shankar S.J.
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