ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
  The drug delivery technology was involving more development and competition in this scientific scenario The Microsponge Delivery System (MDS) is a controlled release technology consists of porous microspheres with tiny sponge like spherical particles with large porous surface. The microsponge drug delivery system typically 10-25 microns in diameter, loaded with active pharmaceutical agent. The microsponge increases the stability, reduces side effects and modifies the drug release. Microsponge systems in which microscopic, polymer based microspheres that suspend and entrap various substances and can be formulated into products such as cream, liquid, powder and gel. Microsponges are used mostly for topical drug delivery and have been recently used for oral administration and tissue engineering



Key words:
 
Microsponge; Controlled release; Topical delivery; Tissue engineering.



June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 17
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 17 / Review Article

MICROSPONGE ROLE IN NOVEL DRUG DELIVERY SYSTEM

Parthiban K.G*1, Manivannan R1,
Krishnarajan D1, Chandra S1, Nidhin Raj1

1Department of Pharmaceutics,
JKK MMRF,College of Pharmacy, Ethirmedu,
Komarapalayam, Namakkal - 638183, Tamilnadu, India

Email:
ntnpharmacy@gmail.com
Parthiban K.G.
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