Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
In an effort to develop potent anti hypertensive drugs, a series of new dihydropyridine analogs were designed on the basis of structure activity relationship properties then minimised and docked against protein 3lv3 using online tools and software’s. Docking studies of dihydropyridine analogs designed by substituting different chemical groups on the phenyl ring at ortho and para positions shows the ligand with the CN as substituent in ortho position of phenyl ring of nifedipine shows good binding affinity towards active site of protein. This studies may paves a new way for better treatment for hypertension.
Key words: nifedipine , hypertensive drugs, dihydropyridine analogs, gocking studies.
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 15
June - 2011 / Volume - 3 / Issue - 04 / /Article No - 15 / Research Article
IN SILICO DRUG DESIGNING AND DOCKING ANALYSIS FOR HYPERTENSION USING NIFEDIPINE AS LEAD MOLECULE
P Harsha Teja*1
1Dept. of pharmaceutical sciences, RGUHS, Bangalore
P. Hersha Teja