Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Azadirachta indica, and Cynodon dactylon are reported to possess wound healing, and anti-bacterial activities. The emulsifying ointment and carbopol -934 gel formulations containing extracts of the above mentioned herbs were formulated and their wound healing activity was studied on experimentally induced open wounds in wrister rats. The individual herbs were evaluated for their standard specification according to the Ayurvedic Pharmacopoeia of India. Extracts were obtained by established procedures. Formulations containing 1%, 2% Azadirachta indica and Cynodon dactylon herbal extracts formulations were prepared and applied topically two times a day to open wounds for 16 days post-operatively and compared with base control. The treated wounds showed a faster rate of wound contraction compared with controls. The wound contraction studies revealed that the wound contractions increase with an increase in the herbal extract concentration. The results obtained were encouraging and honey based formulation produced better healing in all three type wound model compared with the emulsifying ointment and Carbopol gel formulations.
Key words: Azadirachta indica; Cynodon dactylon, Honey; Incision, Dead space wound, Excision.
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 12
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 12 / Practical Research Article
PROMOTION OF CUTANEOUS WOUND HEALING BY HERBAL FORMULATION CONTAINING AZADIRACHTA INDICA AND CYNODON DACTALON EXTRACT IN WISTAR RATS
Vinod Madhaorao Thakare*,
Dr. R. Y. Chaudhari., Dr. V. R. Patil.
1TVESís Honíble Loksevak Madhukarrao Chaudhari,
College of Pharmacy, Faizpur, Dist: Jalgaon, MH, India