Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Malaria, especially that caused by Plasmodium falciparum is the world most devastating human parasitic infection. Malaria afflicts nearly 500 million people and causes some two million deaths each year. Inexpensive and safe drugs, insecticides and ultimately vaccines still are needed to combat malaria. Coccinia grandis, family-Cucurbitaceae, possesses significant antidiabetic property. Other plants in the family Cucurbitaceae possessing diuretic, aphrodisiac, bitter stomachic, purgative and emetic properties. But antiparasitic activity of C. grandis has not been evaluated extensively. We have paid more importance on in vivo antimalarial activity of the plant utilizing Plasmodium berghei parasite on Swiss albino mice. Aqueous extract showed more significant reduction of parasite count. Parasites were stained using Giemsa stain and counted under binocular microscope and compared with control and reference groups. Blood enzymes, protein, urea, biochemical estimations of organs and mean survival times were determined for comparative study. Aqueous leaf extract of Coccinia grandis was screened for blood schizonticidal activity against chloroquin sensitive Plasmodium berghei parasites on Swiss albino mice.
Key words: Parasitic infection, in vivo, Plasmodium berghei, parasite count, mean survival times
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 11
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 11 / Research Article
IN VIVO ANTIMALARIAL ACTIVITY OF THE PLANT COCCINIA GRANDIS. (FAMILY: CUCURBITACEAE)
Bolay Bhattacharya1, Soma Ghosh1, Gouranga Das1
1Division of Microbiology,
Department of Pharmaceutical Technology,
Jadavpur University. Kolkata -700032, India.