Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Present investigations were carried out for evalution of antitumor and antioxidant activity of Ethanolic extract of vitis vinifera L.Leaves. For its antitumor, antioxidant activity in Ehrlich ascites carcinoma (EAC) induced swiss albino mice. The antitumor effect and antioxidant role was assessed using tumor volume, packed cell volume and estimation of liver LPO and antioxidant enzymes such as SOD, CAT. The Ethanolic extract administered at 200 and 400 mg/kg b.w.per day for 14 days, after 24 hours of tumor inoculation. Treatment with extract at a dose of 200 and 400 mg/kg increased mean survival time. Treatment with extract also decreased the levels of LPO and increased the levels of superoxide dismutase, catalase.The results suggest that ethanolic extract of vitis vinifera possess significant antitumor, antioxidant effects in EAC tumor bearing mice.
Key words: vitis vinifera L. Leaves, Ehrlich ascites carcinoma, superoxide dismutase, catalase, lipid peroxidase.
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 10
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 10 / Research Article
EVALUATION OF ANTITUMOR AND ANTIOXIDANT ACTIVITY OF VITIS VINIFERA L. AGAINST EHRLICH ASCITES CARCINOMA INDUCED MICE.
Vaishali J.Mahadik*1, Piyusha B.Patil1,
Sandip B. Patil1, Nilofar S. Naikwade1.
1Department of pharmacology,
Appasaheb Birnale College of Pharmacy,
Sangli, 416416, India.