Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Swellable core osmotic pump technology (SCOT) comprises of Bilayered tablets. One layer as the active layer and the other comprising of the swellable polymer. The developed formulations are subjected to various evaluations like the effect of the polymer, osmogens and orifice size. The invitro release data obtained clearly shows Expotab as the efficient polymer for the system. On the other hand 0.9mm was selected as the optimum orifice size. The SCOT was found to release the drug, Ketoprofen at controlled rate following zero order kinetics. The SCOT may be used in the controlled drug deliver field for the insoluble drugs.
Key words: Ketoprofen, Osmotic pump, Controlled drug delivery, Swellable core osmotic pump technology, zero order.
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 7
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 7 / Review Article
FORMULATION AND INVITRO EVALUATION OF KETOPROFEN OSMOTIC DRUG DELIVERY SYSTEM USING SWELLABLE CORE OSMOTIC PUMP TECHNOLOGY(SCOT).
K Mohammed Maideen1, R.Kumaravelrajan1
1Department of Pharmaceutics,
C.L.Baid Metha College of pharmacy, Chennai-97