Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
The aim of the present study was to investigate antihyperglycemic potential of methanolic bark extract of Madhuca indica on streptozotocin induced diabetes. Type 2 diabetes was induced by administering intraperitoneal injection of a freshly prepared STZ solution (60 mg/kg of body weight) in 0.1M cold citrate buffer to the overnight fasted rats. Animals with blood glucose values above 250 mg/dL on day 3 of STZ injection were considered as diabetic rats. The treatment was started after day 5 of diabetes induction and was considered as day 1 of treatment. After oral administration of 150 and 300 mg/kg of the methanolic extract of Madhuca indica, a significant reduction was observed in the blood glucose level of STZ induced diabetic rats. Present finding demonstrated the significant antidiabetic activity of methanolic bark extract of Madhuca indica.
Key words: Madhuca indica, anti hyperglycemic activity, glucose tolerance test, streptozotocin.
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 3
June - 2011 / Volume - 3 / Issue - 04 / / Article No - 3 / Research Article
ANTI-DIABETIC ACTIVITY OF THE METHANOLIC EXTRACT OF MADHUCA INDICA ON NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS
Anil Bhandari2, A.Pandurangan1
1Department of Pharmacy Bharat Institute of Technology,
Partapur, By-Pass road, Meerut-250103, India
2Jodhpur pharmacy college, Jodhpur, Rajasthan, India, 342003