ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
 
A simple, accurate and precise validated RP-HPLC method for determination of Galantamine Hydrobromide has been developed. Analysis was carried out on Agilent HPLC system with intersil BDS C18, 150mn X4.6mn using Ammonium phosphate buffer and Acetonitrile in the ratio of 60:40v/v  in Isocratic mode as mobile phase with flow rate of1.5 ml.min-1. The detection was carried out using UV detector set at 220 nm. For this method, Beer’s law is obeyed in the concentration range of 10 to 50 µg mL-1 of Galantamin Hydrobromide. The developed method has been successfully applied for the analysis of drug in bulk and pharmaceutical  formulations.


Key words:
 
Galantamine Hydrobromide, RP-HPLC,Method development and validation.


June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Article No 2
June - 2011 / Volume - 3 / Issue - 04 / / Article No -2 / Research Article

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF GALANTAMINE HBR IN CAPSULE DOSAGE FORM BY RP-HPLC METHOD

Anbarasi B*1, 
Dileep surya K
1, Senthilkumar N1.

1
Department of Pharmaceutical Analysis,
J.K.K. MMRF College of Pharmacy,
B.komarapalayam, Namakkal, Tamilnadu, India

Email:
arasi7322@gmail.com
Anbarsi B.
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