Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
In the work, for the first time, the investigation was carried out to determine the chemical composition of fatty acids methyl esters (FAME) bark of Nyctanthes arbortristis were successively extracted by light petroleum ether (40-600C bp.)-n-hexane-chloroform (PHCL), which analyzed by gas liquid chromatography (GLC).
GLC analysis of fatty acid methyl ester of PHCL extract led to identification of 21 compounds. This analysis revealed that contains Nyctanthes arbortristis bark mainly palmitic acid (C16:0, 16.44%), oleic acid (C18:1, 13.30%), behenic acid (C22:0, 24.80%), nervonic acid (C24:1, 12.39%).
Key words: Nyctanthes arbortristis Linn (Seuli), bark, fatty acid composition.
June 2011 Issue
June - 2011 / Volume - 3/Issue - 04
( Total Articles =30 )
Md. M. Rahman
Article No 1
June - 2011 / Volume - 3 / Issue - 04 / Article No - 01 / Research Article
ANALYSIS OF FATTY ACID COMPOSITION OF NYCTANTHES ARBORTRISTIS LINN BARK BY GAS LIQUID CHROMATOGRAPHY
Mohammad Mizanur Rahman*,
1Department of Chemistry,
Government Jagannath College
(present name: Jagannath University),