Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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The ethanolic extract of Phyllanthus niruri and Mimosa pudica leaves was investigated for antimalarial activity against Plasmodium berghei infections in mice. The median lethal dose was determined to ascertain the safety of the extract in mice. The antimalarial activities during early and established infections were evaluated. Phytochemical screening was also investigated to elucidate the possible mechanism of the antimalarial properties. The extract of P.niruri and M.pudica leaf demonstrated significant antiplasmodial activity in all the three models of the antimalarial evaluations. Phytochemical screening revealed the presence of some vital antiplasmodial constituents such as terpenoids ,flavonoids and alkaloids. The leaf extract of P.niruri and M.pudica thus possesses antimalarial activity, which explains the rational usage of this plant in traditional medicine.
Key words: P.niruri and M.pudica ; ethanolic extract; antimalarial activity.
May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 24
May - 2011 / Volume - 3 / Issue - 03 / Article No - 24 / Research Article
ANTIMALARIAL ACTIVITY AND PHYTOCHEMICAL SCREENING OF ETHANOLIC LEAF EXTRACT OF PHYLLANTHUS NIRURI AND MIMOSA PUDICA
1Department of Zoology,School of Life sciences,
Bharathiar University, Coimbatore- 46,
Tamil Nadu, India.