ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
Convolvulus arvensis is a common weed found throughout the India and Pakistan and is traditionally used as a laxative. The diuretic effect of the Convolvulus arvensis root extracts were assessed in rats using furosemide as standard diuretic drug. The parameters studied on individual rat were body weight before and after test period, total urine volume, urine concentration of Na+, K- and Cl-.  The water and ethanol extracts (50 and 100 mg/kg) of the plant produced time-dependent increase in urine output. Electrolyte excretion was also significantly affected by the plant extracts. The water extract increased the urine excretion of Na+, K+ and HCO3-. In contrast, the ethanol extract increased the excretion of HCO3-, decreased the loss of K+ and had little effect on renal removal of Na+. The high-ceiling diuretic, furosemide, increased the renal excretion of Na+ and Cl-; but had no effect on K+ and HCO3- loss.



Key words:
 
Diuretic activity, Furosemide, Convolvulus arvensis.

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May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 23
May - 2011 / Volume - 3 / Issue - 03 / Article No - 23 / Research Article


CONVOLVULUS ARVENSIS - L. ROOT EXTRACTS INCREASE URINE OUTPUT AND ELECTROLYTES IN RATS.


Vipin Sharma1*
,Pooja Verma1


1Gyan Vihar University, Jaipur,
Rajasthan, India.
Email:vipinsharmaggn@rediffmail.com
Vipin Sharma