ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
Welcome to "International Journal of Pharmaceutical Research and Development"  i.e. "IJPRD"
HOW TO PREPARE   
YOUR PAPER
What's New | Feedback | Copyright and Disclaimer
Online Since : March 2009
TODAY IS
Abstract Content
Model Abstract
Summary Content
Model Summary

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
- : BACK TO CURRENT ISSUE OF JOURNAL :-
((( PREVIOUS ARTICLE
NEXT ARTICLE )))
ABSTRACT
  
 
Inflammation is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process of the tissue. A cascade of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. All the steroidal and non-steroidal anti-inflammatory drugs (NSAIDs), which have been used were heterogeneous group of compounds with pharmacological properties and side effects are probably poly competent in that they are able to modulate more than one mediator or cellular event concerned with the inflammatory response. Hence our study focuses on the anti-inflammatory and analgesic activity of methanolic extract of powdered ripe fruit flesh of Cucurbita pepo Linn. in three different doses (100, 200 &300 mg/kg bw) on Carrageenan and formalin induced inflamed rats against standard drug indomethacin (10 mg/kg bw). Results were reported as mean SD. It was concluded from these studies that the extract prepared from Cucurbita pepo Linn possess potential anti-inflammatory and analgesic activity which was comparable with standard drug indomethacin. Even though all the concentrations showed varying degree of inflammatory and analgesic activity, 300mg/kg bw showed better inflammatory and analgesic activity.


Key words:
 
anti inflammatory, analgesic activity, Cucurbita pepo Linn, Indomethacin
[ VIEW FULL ARTICLE ] [PDF VIEW ]
May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 22
May - 2011 / Volume - 3 / Issue - 03 / Article No - 22 / Research Article


EFFECT OF DIFFERENT DOSES OF CUCURBITA PEPO LINN EXTRACT AS AN ANTI-INFLAMMATORY AND ANALGESIC NUTRACEAUTICAL AGENT ON INFLAMED RATS


Thirunethiran Karpagam1*,
B.Varalakshmi1 ,
J.Suguna Bai2 , S.Gomathi1


1Department of Biochemistry,
Shrimati Indira Gandhi College, Tiruchirappalli-620002.
2Department of Biochemistry,
Seethalakshmi Ramaswamy College,(Autonomous)
Tiruchirappalli-620002.
Email:karpagam_murugan@yahoo.com
T. Karpagam