Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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Over the past three decades, rapid disintegrating tablets have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. Generally, elderly people experience difficulty in swallowing the conventional dosage forms (tablets, capsules, solutions and suspensions) because of tremors of extremities and dysphasia. Rapid disintegrating drug delivery systems may offer a solution for these problems. Oral delivery is currently the gold standard in the pharmaceutical industry where it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance.
Rapid disintegrating tablets (RDT) are useful in patients, such as pediatric, geriatric, bedridden, or developmentally disabled, who may face difficulty in swallowing conventional tablets or capsules and liquid orals or syrup, leading to ineffective therapy, with persistent nausea, sudden episodes of allergic attack, or coughing for those who have an active life style. The objective of this article is to review the development of RDTs, challenges in formulation, new RDT technologies and evaluation methodologies, suitability of drug candidates, and future prospects.
Key words: Rapid disintegrating tablet, Enhanced bioavailability, Superdisintegrants, Rapid disintegrating technologies, Evaluation,
May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 21
May - 2011 / Volume - 3 / Issue - 03 / Article No - 21 / ReviewArticle
AN APPROACH FOR RAPID DISINTEGRATING TABLET : A REVIEW
Tarique Khan*1, Sayyed Nazim1,
Siraj Shaikh1, Afsar Shaikh1,
Ashish Khairnar1, Aejaz Ahmed1.
11.Ali-Allana College of pharmacy,
N.M.U, Akkalkuwa Dist.Nandurbar
425-415, (M.S), India.