Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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To know the in vitro antibacterial activity of both the ethanolic and methanolic extracts of Saraca indica (Family-Caesalpinaceae), present study was conducted. Both the extracts were used at 100 µg /ml and 200 µg /ml. The largest zone of inhibition was produced when ethanolic extract (100µg/ml and 200 µg g/ml) was used against Escherichia coli, zone was least in case of Staphylococcus aureus. However, methanolic extract
(100 µg /ml and 200 µg /ml) gave maximum zone of inhibition against Staphylococcus aureus and it was minimum in case of Bacillus subtilis. Although our extracts were inferior to the positive control (chloramphenicol) as far as zones of inhibition were concerned, the differences between the zones of inhibition produced by the positive control and the extracts against Escherichia coli and Bacillus subtilis were not remarkable .So, it may be concluded that both the extracts, even at low concentration, possess antibacterial activity.
Key words: Saraca indica, methanolic extract, ethanolic extract, antibacterial activity
May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 19
May - 2011 / Volume - 3 / Issue - 03 / Article No - 19 / Research Article
ANTIBACTERIAL ACTIVITY STUDY OF SARACA INDICA LEAVES EXTRACT
Sarojini Nayak*, Anjulata Manjari Sahoo,
Chandra Kanti Chakraborti, Md Nasrul Haque.
1Kanak Manjari Institute of Pharmaceutical Sciences,
Rourkela, Orissa-769015, India