Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Synergistic therapeutic effects may complicate the dosing of long-term medications. A basic problem is that the phrase "herb-drug interaction" routinely appears in the media, without definition and an assumption that everyone knows what is meant. Recent research estimates 50% of adult Americans use at least one prescription medication and 7% of adult Americans take 5 or more prescription drugs. Among prescription drug users, 16% also take herbal supplements 7 however the prevalence of clinically significant interactions between herbals and medications is unknown. Interactions between herbals and medications can be caused by either Pharmacodynamic or pharmacokinetic mechanisms. Fugh-Berman and Ernst have developed a rubric for the determination of the reliability of case reports on drug- herbal interactions. Pharmacist can play a vital role in preventing drug herb interaction to occur by appropriately dispensing medicine and taking due care of patientís history and medication profile.
Now present condition patients taking both ayurvedic and allopathic treatment remain aware of potential herb-drug interaction and avoid taking medications .which might prove hazardous to their already deteriorating health. This article provides brief idea about pharmacist can change the present scenario and utilize their knowledge in providing healthy information about herb-drug interaction.
Key words: herb-drug interaction, Pharmacodynamic, pharmacokinetic mechanisms. . .
May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 17
May - 2011 / Volume - 3 / Issue - 03 / Article No - 17 / Review Article
A REVIEW ON HERB-DRUG INTERACTIONS
K.Mahesh C. MadhusudhanChetty
1Annamacharya College of Pharmacy,
New Boyanapalli, Rajampet, Kadapa - 516126,
Andhra Pradesh, India.