Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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The Zizyphus rugosa lam, family Rhamnaceae roots powder was extracted with Chloroform and methanol and then screened for its anti microbial potential against various gram (+)ve and (-)ve organisms using the cup - plate agar diffusion method. The results revealed that, the chloroform and methanolic extracts exhibited significant anti microbial activity and anti fungal activity at concentrations of 150 mg/ml and 300 mg/ml against tested organisms, but was more effective against, B.Subtilis, B. Pumillis E.coli, and on Fungi C. albicans. We also observed that the chloroform extract, showed grater degree of inhibition of the zone in comparison to the methanolic extract.
Key words: Zizyphus rugosa, Anti bacterial, Anti fungal.
May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 14
May - 2011 / Volume - 3 / Issue - 03 / Article No - 14 / Research Article
ANTI BACTERIAL AND ANTI FUNGAL POTENTIAL OF ROOTS OF ZIZYPHUS RUGOSA
P. Rambabu*1, K. Venkata Ramana1,
1Pharmacognosy and Phytochemistry
Division, A.S.N. Pharmacy College, Tenali, AP, India
2Pharmacognosy and Phytochemistry Division,
University College ofPharmaceutical Sciences,
Andhra University, Visakhapatnam