ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
 
A simple, rapid and accurate spectrophotometric method has been developed for quantitative estimation of Tenofovir Disoproxil Fumarate in bulk and tablet. In methanol Tenofovir Disoproxil Fumarate exhibits absorption at 260.0 nm and method obeys Beer’s law at the concentration range of 10-100 µg/mL. The percentage label claim was found in the range of 98-103%. The proposed method was validated statistically and recovery studies.



Key words:
 
Tenofovir Disoproxil Fumarate, UV Spectrophotometric Method, Tablet.

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May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 11
May - 2011 / Volume - 3 / Issue - 03 / Article No - 11 / Research Article

UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE TABLET DOSAGE FORM



Prasanna A. Nevase
1*, Hemalata M. Nimje1,
Rajesh J. Oswal1, Rishikesh V. Antre1,
Sandip S. Kshirsagar1

1JSPM’s Charak College of Pharmacy and Research,
Pune-Nagar road, Wagholi, Pune-412 207
Email: jspmpharmacy@gmail.com
P. Nevase