Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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Present study is aimed to evaluate the anthelmentic activity of fresh fruit juice of Citrus aurantium L. against Indian earthworms Pheritima posthuma. The various dilutions of fresh fruit juice of Citrus aurantium L. were tested for paralysis time and death time of the worms. Results revealed that all the dilutions of tested fresh juice of Citrus aurantium L. possess anthelmentic activity in a dose dependant manner. Potency of the test samples was found to be inversely proportional to the time taken for paralysis/death of the worms. The activities were comparable with the reference drug Albendazole. Among the tested fresh undiluted fruit juice was found to possess promising anthelmentic activity in comparison to fresh diluted fruit juice. Phytoconstituents of fresh fruit juice of the Citrus aurantium L. were found to be Alkaloids, Carbohydrates, Flavonoids, Phenolic/ Tannins, Glycosides. The present study therefore justifies its use in the folklore remedies as an anthelmentic drug of natural origin.
Key words: Anthelmintic, Citrus aurantium L., Pheritima posthuma, Albendazole.
May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 10
May - 2011 / Volume - 3 / Issue - 03 / Article No - 10 / Research Article
ANTHELMENTIC ACTIVITY OF CITRUS AURANTIUM LINN.
Bidkar J S1*, Bhujbal M D1,
Ghanwat D D1, Dama G Y1
1SGMSPM’s Sharadchandra Pawar
College of Pharmacy,
Otur, Pune - 412 409, MH, India
Bidkar J. S.