Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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The objective of this study was to evaluate the anti-inflammatory activity of methanolic leaf extract of Cyathea gigantea (LCG) by using carrageenan induced hind paw-oedema model. Cyathea gigantea (Wall. ex Hook. ) is a tree fern and its leaves were used traditionally for the treatment of body ache. The methanolic leaf extract of Cyathea gigantea at the doses of 200, 400 and 800 mg/kg b.w., produced dose dependent significant reduction (p<0.05–0.001) in carrageenan-induced rat maximal paw oedema by 19.76±1.15%, 31.01±0.85% and 39.07±1.09%, and the standard drug Indomethacin at dose 1.3×10-5 moles/kg reduced oedema by 62.01±1.71% respectively and the total (AUC) paw oedema by 19.83±1.32%, 36.03±1.82%, 43.03±2.59%, and Indomethacin at dose 1.3×10-5 moles/kg reduced total(AUC)paw oedema by 69.09±1.1% respectively. The results suggested that the plant Cyathea gigantea possessing in-vivo anti-inflammatory activity.
Key words: Cyathea gigantea, carrageenan, anti-inflammatory activity, Indomethacin.
May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 9
May - 2011 / Volume - 3 / Issue - 03 / Article No - 9 /Survey Article
ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC LEAF EXTRACT OF CYATHEA GIGANTEA (WALL. EX HOOK. )
P. Madhukiran1*, B.Ganga Rao1
1A.U College of Pharmaceutical Sciences,
Andhra University, Visakhapatnam 530 003.