ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
 
One of the major challenges facing the pharmaceutical industry today is finding new  ways to increase productivity, decrease cost while still ultimately developing new therapies to enhance health. Bioanalytical technologies plays very important role in this. This review discusses the conceptual aspects of method validation, its management, processes and schemes and mainly deals with  its important parameters and their significance. Bioanalytical method validation includes all the procedure thst demonstrate that aparticular method used for quantitative measurement of analytes in a given biological matrix is selective, sensitive, reliable and reproducible for the intended use. Selective and sensitive analytical methods for quanitative evaluation of drugs and their metabolites are critical for uccessful conduct of  pharmacological studies.




Key words:
 
Method validation, Mass spectrometry, Stability studies

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May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 7
May - 2011 / Volume - 3 / Issue - 03 / Article No - 7 / Review Article

BIOANALYTICAL TECHNOLOGIES: A REVIEW TO METHOD VALIDATION


Gandharv Sharma1*,

Akash Jain1

1M.M College of Pharmacy,
Maharishi Markendeshwsar University,
Ambala, India-133203
Email:scoob.gandharv@gmail.com
Gandharv Sharma