ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
 
Atenolol is a Ŗ1 selective antagonist without membrane stabilizing or intrinsic sympathomimetic activities.  Administration of conventional tablets of atenolol has been reported to exhibit fluctuation in the plasma drug levels, resulting either in manifestation of side effects or reduction in drug concentration at the receptor site. In the present study an attempt has been made to prepare melt-in-mouth tablets (MMT) of atenolol with enhanced dissolution rate. The fast dissolving tablets of atenolol was prepared using various concentrations of subliming agents like ammonium bicarbonate, camphor, menthol, thymol, phthalic anhydride by direct compression method. The blend was examined for angle of repose, bulk density, tapped density, total porosity, compressibility index and Hausnerís ratio.   The prepared tablets were evaluated for weight variation, hardness, drug content, friability, thickness, diameter, disintegration time, Wetting time and dissolution rate. An effective pleasant testing formulation released 96.95% drug within 1 minute. It was concluded that Sublimation technique is a useful method for preparing mouth dissolving tablets by direct compression method


Key words:
 
Mouth dissolving tablets, Atenolol, Ammonium bicarbonate, Camphor, Menthol, Phthalic anhydride.
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May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 5
May - 2011 / Volume - 3 / Issue - 03 / Article No - 5 / Research  Article

DEVELOPMENT AND CHARACTERIZATION OF MELT-IN-MOUTH TABLETS OF ATENOLOL BY SUBLIMATION TECHNIQUE


Lakshmi CSR*1
,Sagar Pravin Akul1,
Anup Vijay Totala1, Jitesh Jagdish Chaudhary1,
Nitesh Jagdishbhai Patel1, Vedhavati S.V.1

1Nargund college of pharmacy
II main, Banshankari III stage,
Hoskarehalli cross, Dattatreya nagar,  Bangalore-560085
E-mail:csrlakshmi_1971@yahoo.co.in
Dr. Laxmi CSR