ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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ABSTRACT
  
Mouth dissolving tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. In view of enhancing bioavailability an attempt has been made to study three different methods direct compression, effvercent and sublimation in formulation of mouth dissolving tablets of Granisteron HCl. Total Six formulations using various superdisintegrants, subliming agents and different ratio of sodium bicarbonate : citric acid were prepared. All prepared formulations were evaluated for physico-chemical parameters. The formulations exhibited good disintegration properties with total disintegration time in the range of 20 to 35 s. Comparative evaluation of three methods showed direct compression method is a better than effervescent method than sublimation method as its formulations rapidly disintegrate in oral cavity. In vitro cumulative percentage drug release for formulations prepared by direct compression with explotab superdisintegrants shows 98.79%, effervescent method with 12:6 ratios of sodium bicarbonate: citric acid shows 95.05% while sublimation method using camphor shows 92.13% releases in 12 min. Kinetic studies indicated that all the formulations followed first order release with diffusion mechanism.


Key words:
 
Mouth dissolving tablets, Granisteron HCl, effervescent method, diffusion mechanism.
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May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 4
May - 2011 / Volume - 3 / Issue - 03 / Article No - 4 / Research Article

DEVELOPMENT OF MOUTH DISSOLVING TABLETS OF GRANISETRON HYDROCHLORIDE USING THREE DIFFERENT TECHNIQUES

Bharat V. Jain
1*, Rupali R. Patil1.
Sonali S. Wankhede1,
Dipak R. Patil1, Dr. Shashikant D. Barhate1

1
Smt. Sharadchandrika Suresh Patil College of Pharmacy,
Chopda-425107, Maharashtra, India

Email :
bharatjain2006@gmail.com 
Bharat Jain