ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
 
In this study, the methanol extracts and their different organic soluble fractions i.e. pet-ether, carbon tetrachloride, chloroform and aqueous soluble fractions of Mesua nagassarium and Kigelia Pinnata were subjected to study for membrane stabilizing activity. The extractives inhibited heat- as well as hypotonic solution-induced haemolysis of erythrocytes in vitro.
The pet-ether soluble fraction (PESF) of M. nagassarium inhibited 49.19 % and 23.73% whereas pet-ether soluble fraction (PESF) of K. pinnata demonstrated 65.7% and 32.03% inhibition of hemolysis of RBC caused by hypotonic solution and heat, respectively. Here acetyl salicylic acid was used as reference standard at 0.10 mg/mL.




Key words:
 
Mesua nagassarium, Kigelia Pinnata, membrane stabilizing activity.

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May 2011 Issue
May - 2011 / Volume - 3/Issue - 03
( Total Articles =25 )
Article No 1
May - 2011 / Volume - 3 / Issue - 03 / Article No - 01 / Research Article


MEMBRANE STABILIZING ACTIVITY - A POSSIBLE MECHANISM OF ACTION FOR THE ANTI-INFLAMMATORY ACTIVITY OF TWO BANGLADESHI MEDICINAL PLANTS: MESUA NAGASSARIUM (BURM.F.) AND KIGELIA PINNATA (JACK.) DC.

Mohammad A. Rashid2*
,Md. Al Amin Sikder 1,
Mohammad. A. Kaisar2,
Md. Kowser Miah1, Md. Masud Parvez1,
A.K.M. Nawshad Hossian1,

1Department of Pharmacy, State University of
Bangladesh, Dhaka-1205, Bangladesh
    2Department of Pharmaceutical Chemistry,
Faculty of Pharmacy, University of Dhaka,
Dhaka-1000, Bangladesh
Email:rashidma@univdhaka.edu
Md. A. Rashid