ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
  
A series of novel 8-substituted-2-methyl-4-(substituted-aniline)-1,5-benzothiazepine was prepared by the reaction of  8-substituted-2-amino-benzenethiol with acetoacetate-2-chloro-anilide in presence of glacial acetic acid, All synthesized compounds were tested for their Antifungal activity against candida albicans and fusarium oxysporum. Itís interesting to note that 4th position of synthesizied compounds displayed notagible antifungal activity.




Key words:
2-aminobenzenethiol,1,5-benzothiazepines,heterocyclic,fungicial activity.


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April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 25
April - 2011 / Volume - 3 / Issue - 02 / Article No - 26 / Research Article


SYNTHESIS OF SOME NEW 8-SUBSTITUTED-1, 5-BENZOTHIAZEPINES                                                              DERIVATIVES AND DETERMINATION OF THEIR FUNGICIDAL ACTIVITY


Radhey shyam*1,Vijay Singh Ghorela2,
V.K.singh1, Sakshi shah2


1Seth G. B. Podar collage.
Department of Chemistry Nawalgarh,
Rajasthan. India
2Punjabi university Patiala (Punjab), India
Email:vijay_ghorela@rediffmail.com
Radhey Shyam