Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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The aim of present investigation was to improve the flowability and compressibility of poorly compressible drug (Naproxen) which could be helpful for preparation of tablets by direct compression method; to characterize the molecular status of the drug in the tablet; to evaluate the mechanical properties of the compact; to evaluate the dissolution rate of the compact; conversion in solid (tablet) dosage form. Prototype formulation development was done by physically mixing Naproxen, MCC (PH101) and talcum in different ratios (1:1; 2:1; 3:1). Preparation of tablet by direct compression method was done using MCC (PH101) and talcum in different ratios and characterization of mechanical properties were done. Physicochemical characterization of the drug in the formulation was done by in vitro dissolution study; molecular interaction study. These studies resulted in enhanced flowability, packability, compressibility, compactibility along with drug dissolution properties. The compaction process enhanced drug dissolution relative to drug alone and also relative to corresponding loosely mixed physical mixtures.
Key words: compressibility, naproxen, physicochemical characterization, in vitro dissolution study, compressibility
April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 24
April - 2011 / Volume - 3 / Issue - 02 / Article No - 24 / Research Article
PREPARATION AND PHYSICOMECHANICAL CHARACTERISATION OF NAPROXEN TABLETS BY DIRECT COMPRESSION METHOD
Sunita Rani Patra 1*,
Chandan Kumar Giri 2, Subrata Mallick 3
1Department of Pharmaceutics, Dadhichi College
of Pharmacy, Sundargram, Cuttack, Orissa
1Department of Quality Assurance, Appasaheb
Birnale College of pharmacy, Sangli, Maharashtra
3School of Pharmaceutical Sciences,
SOA University, Bhubaneswar, Orissa