Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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Transdermal drug delivery systems are also known as patches, containing dispersed or dissolved drug with plasticizers, polymers, etc, are intended to deliver a therapeutically effective amount of drug across the skin. In the present work, Transdermal drug delivery of valsartan were formulated in different concentration (10%, 20% and 30% ) of glycerin as plasticizer and a blend of two in different concentrations of polymers (PVPK30, HPMC and Eudragit RS 100) were formulated by solvent casting method. Drug polymer interaction study was carried out using FTIR. Other characteristics were confirmed by XRD and SEM studies. The formulated valsartan patches exhibited good physicochemical characteristics. In-vitro diffusion studies were performed in phosphate buffer pH 7.4 at ? max 260nm, by using cellophane membrane (0.45µ) in an artificial Keshary chein diffusion cell. In this study the results indicates, as increase in the concentration of glycerin, increases the diffusion rate of valsartan patches. Among polymers, the combination of Eudragit RS 100 with HPMC had increased diffusion rate. The diffusion data were fitted in various models to aces the kinetics and mechanism of diffusion.
Key words: Valsartan, Eudragit RS 100, HPMC, Keshary- chein diffusion cell.
April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 23
April - 2011 / Volume - 3 / Issue - 02 / Article No - 23 / Research Article
DESIGN AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM OF VALSARTAN USING GLYCERINE AS PLASTICIZER
Gulam Irfani1*, Raga Sunil raj1,
Amit Tondare1, Noola Shivanand1.
1Department of Industrial Pharmacy,
KRE’s Karnataka College of Pharmacy,
Bidar - 585403, Karnataka, India