ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
Copyright 2009  by "International Journal of Pharmaceutica Research and Development"    All Rights reserved    E-Mail: info@ijprd.com
Welcome to "International Journal of Pharmaceutical Research and Development"  i.e. "IJPRD"
HOW TO PREPARE   
YOUR PAPER
What's New | Feedback | Copyright and Disclaimer
Online Since : March 2009
TODAY IS
Abstract Content
Model Abstract
Summary Content
Model Summary

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
- : BACK TO CURRENT ISSUE OF JOURNAL :-
((( PREVIOUS ARTICLE
NEXT ARTICLE )))
ABSTRACT
  
  
Esomeprazole Magnesium Trihydrate, very slightly soluble (0.3mg/ml) proton pump inhibitor belongs to Class II of BCS with elimination half life of 1-1.5 hrs. The aim of present study was to prepare inclusion complexes with improved solubility of Esomeprazole Magnesium Trihydrate and to find out the best suitable complexing agent for solubility enhancement of drug. For the purpose, inclusion complexes (C1-C10) of Esomeprazole Magnesium Trihydrate were formulated with Complexing Agents (1:1.5-1:5.5 molar ratio). 2-Hydroxy Propyl--Cyclodextrin (C1-C5) and Ethylene Di-amine Tetra Acetic Acid Disodium Salt (C6-C10) were taken as complexing agents. As per results, Complexing agents contributed to solubility enhancement of drug. Comparative solubility study was performed to find out more suitable complexing agent among the two. Solubility profile of inclusion complexes (C3 & C7) were found to revealed the 15-20 FOLD
increase in solubility of pure drug. Dissolution Profile of inclusion complex tablets showed high release rate indicating improvement in  solubility and dissolution of drug and Formulation C7 (1:2.5 molar ratio of Esomeprazole Magnesium Trihydrate : Ethylene Diamine Tetra Acetic Acid Disodium Salt) showed maximum drug release. In present study, we have concluded that with a best suited ratio of 1: 2.5 (drug: EDTA), Ethylene Diamine Tetra Acetic Acid Disodium Salt was better complexing agent.


Key words:
Esomeprazole Magnesium Trihydrate, 2-Hydroxy Propyl--Cyclodextrin, Ethylene Diamine Tetra Acetic Acid Disodium Salt, Inclusion Complex, Inclusion Complex tablet, Solubility Enhancement.

[ VIEW FULL ARTICLE ] [PDF VIEW ]
April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Sugandha V.
Article No 21
April - 2011 / Volume - 3 / Issue - 02 / Article No - 21 / Research Article


COMPARATIVE STUDY OF 2-HYDROXY PROPYL-BETA-CYCLODEXTRIN AND ETHYLENE DIAMINE TETRA ACETIC ACID DISODIUM SALT AS COMPLEXING AGENTS FOR SOLUBILITY ENHANCEMENT OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE BY COMPLEXATION

       Sugandha Varshney*1,
Dr. Mathew George1 ,
Ajay Kumar Tiwari2, Pushpa Brijwal2


1Department of B.Pharmacy, Shree Dev Bhoomi
Institue of Education,Science and  
  Technology, Dehradun-India
3School of Pharmaceutical Sciences,
Jaipur National University, A Venture of Seedling 
   Group of Institutions, Jagatpura, Jaipur - 302025, India
Email:sugandha.varshney1986@gmail.com