Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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In the present study microspheres containing felodipines were prepared by Solvent evaporation method and characterized by optical microscopy and scanning electron microscopy. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and In-vitro release pattern. The effect of process variables on microsphere size was studied and based on these preliminary studies, different batches of microspheres were prepared by altering the drug: polymer ratio and cross-linking with calcium chloride. The size of microspheres was in range of 130-140µm. They were spherical in shape as evidenced by photomicrographs and scanning electron microscopy. The percent drug entrapment was in the range of 86-88 % and they could sustain drug release over a period of 8 hrs.
Key words: Felodipine, sodium alginate, calcium chloride, groundnut oil, solvent evaporation method, primary emulsion.
April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 19
April - 2011 / Volume - 3 / Issue - 02 / Article No - 19 / Research Article
FORMULATION AND EVALUATION OF FLOATING FELODIPINE MICROSPHERE
Sagar Balaso Sangale1*,
Dr. S. D. Barhate1, B.V. Jain1,
1Department of Pharmaceutics,
Smt. S.S. Patil College of Pharmacy,Chopda,
Dist-Jalgaon- 425107, Maharashtra, India.