Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
The objective of this study was to evaluate the antioxidant activity of methanolic leaf extract of Cyathea gigantea by using Superoxide radical, Hydroxyl radical and DPPH radical scavenging methods. Cyathea gigantea is a species of scaly tree fern. The methanolic leaf extract of Cyathea gigantea produced a dose dependent inhibition of in vitro free radical generation of superoxide anion (IC50 value 220 µg/ml), hydroxyl radical (IC50 value 351.9 µg/ml) and DPPH radical (IC50 value 203.5 µg/ml). The results clearly indicate the free radical scavenging activity of methanolic leaf extract of Cyathea gigantea and this activity comparable with that of the standard drug ascorbic acid.
Key words: Cyathea gigantea, Antioxidant activity, Ascorbic acid.
April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 12
April - 2011 / Volume - 3 / Issue - 02 / Article No - 12 / Research Article
IN VITRO EVALUATION FOR FREE RADICAL SCAVENGING ACTIVITY OF METHANOLIC LEAF EXTRACT OF CYATHEA GIGANTEA (WALL. EX HOOK.)
B. Ganga Rao1
1A.U College of Pharmaceutical Sciences,
Andhra University, Visakhapatnam 530 003.