Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
The aim of present was to evaluate wound healing activity of methanol extract of bark of Sesbania grandiflora (L.) Poir by using excision wound model in Wistar albino rats. In excision model, treatment was continued till the complete healing of wound. For topical application 2.5%w/w, 5%w/w and 10%w/w ointment of methanol bark extract was prepared by using 2% sodium alginate. The wound healing activity was assessed by the percentage of wound contraction, period of epithelialization. Methanol extract showed significant wound healing activity at 10%w/w dose when compared to standard 1% framycetin sulphate. The percentage wound contraction of control, standard, 2.5%w/w, 5%w/w and 10%w/w on 18th day was found to be 82.01 ± 0.71, 100 ±0.0, 97.51 ± 0.67, 98.88 ± 0.27, 100 ± 0.0. The results confirmed that methanol extract of bark of Sesbania grandiflora (L.) Poir showed significant wound healing activity.
Key words: Sesbania grandiflora (L.) Poir, excision wound model, wound contraction, epithelialization.
April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 10
April - 2011 / Volume - 3 / Issue - 02 / Article No - 10 / Research Article
WOUND HEALING ACTIVITY OF SESBANIA GRANDIFLORA (L.) POIR. BARK
P Karthikeyan*1, V Suresh1, A Suresh1,
J Aldrin bright1, S Senthil velan1,
1Dept. of pharmacology,
JKKMMRF College of Pharmacy, B.Komarapalayam,
Namakkal, Tamilnadu - 638183
2 PGP College of Pharmaceutical science
& Research Institute, Namakkal, Tamilnadu -637207