ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
 
Ondansetron HCl (Ond HCl) is a selective inhibitor of type-3 serotonium(5-HT3) receptor, is an antiemetic. It is an intensely bitter in taste. In the present study an attempt has been made to prepare bitter less fast dissolving tablet of Ond HCl using Eudragit E100 as a taste masking agent. Mass extrution was the technique used for preparing taste masked granules. Drug polymer complexes were tested for drug content, in vitro taste evaluation in simulated salivery fluid (SSF) of pH 6.2 and drug excipient interaction (IR spectroscopy). Complex that did not release drug in SSF was considered taste- masked and selected for formulation fast dissolving tablet. The complex with drug-polymer ratio 1:4 showed less amount of drug release in SSF; therefore, it was selected for further development of formulations. The tablet was prepared indion-414 as superdisintegrant. The blend was examined for angle of rapose, bulk density, tapped density and hausnerís ratio. The tablets were evaluated for hardness, drug content, friability, disintegration time and in vitro drug release study. The tablets disintegrated in vitro with in 20 s and complex drug was released from tablet with in 3 min. Thus, the in vitro study reveals that the prepared formulation is suitable for taste masking of Ond HCl as fast dissolving formulation.



Key words:
Fast dissolving tablets, Ond HCl, taste masking, eudragit E100, indion-414.
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April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 8
April - 2011 / Volume - 3 / Issue - 02 /Article No - 08/
Research Article

DESIGN AND EVALUATION OF FAST DISSOLVING TABLETS OF TASTE MASKED ONDANSETRON HYDROCHLORIDE

Dr. Srinivasa RaoY2,
Doddayya H1,
Shrishail S Patil1, Vamshidhar Reddy, D1

1Department of Pharmaceutics, N. E. T. Pharmacy
College, Mantralayam road, Navodaya nagar,
Raichur-584 103, Karnataka, India
2Vignan Institute of Pharmaceutical Technology,
Beside VSEZ, Duvvada
Visakhapatnam-46, Andhra Pradesh, India
Email: yarraguntla@rediffmail.com
Dr. Srinivasa Rao