ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
 
Tannase production under solid-state fermentation was investigated using isolated Aspergillus terreus. Among all agro -industrial waste material evaluated, wheat bran supported maximum tannase production. Solid material regulated the enzyme production and yield was improved with the supplementation of carbon and nitrogen sources to the solid medium. Maximum enzyme production was achieved with 1.5% Sucrose and 1.75% yeast extract. Glucose did not repress enzyme production but inorganic nitrogen sources showed little negative impact. The physiological fermentation factors such as pH of the medium (pH 3.5) moisture content (60%), incubation time (72 h) and inoculum level (3ml) played a vital role in tannase production. The enzyme production was found to be associated with the growth of the fungal culture          



Key words:
solid State fermentation, tannase, Aspergillus terreus, enzyme extraction

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April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 6
April - 2011 / Volume - 3 / Issue - 02 / Article No -6 / Research Article

PRODUCTION OF TANNASE BY ISOLATED ASPERGILLUS TERREUS UNDER SOLIDSTATE FERMENTATION


Dr. M. Narsi Reddy1*
,C. Ganesh Kumar1

1Chemical Biology Laboratory, Indian Institute of
Chemical Technology, Andhra Pradesh,
Hyderabad- 500 607 
Email:mnreddydr@gmail.com           

Dr. M.N. Reddy