Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
An oral press-coated tablet was developed by means of direct compression to achieve the time-controlled disintegrating or rupturing function with a distinct predetermined lag time and produce sustained drug delivery. This press-coated tablet containing Diltiazem hydrochloride (DIL) as a model drug in the inner core was formulated with an outer shell by different weight ratios of low viscosity grade hydrophilic polymer of Hydroxypropylmethylcellulose (HPMC) 3-cps, 5-cps, 6-cps powder respectively and weight ratio of that used 1:2.86, 1:3, 1:4, 1:5 for each press-coated polymer to core tablet. The release profile of the press-coated tablet exhibited a time period without drug release (time lag) in pH 1.2 followed by a rapid and complete release phase, the lag phase was markedly dependent on the weight ratios of Core. This ratio of core to press coated polymer press coated tablets displayed acid resistance in the stomach. In vitro dissolution test in pH 6.8 the release of press-coated tablet shows sustained drug release and to avoid gastrointestinal disturbances.1:3 weight ratio shows better sustained release action then other.
Key words: Press-coated tablet, time lag, HPMC, weight ratio, sustained release.
April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 4
April - 2011 / Volume - 3 / Issue - 02 / Article No - 4 / Research Article
FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE PRESS-COATED TABLET
Kapse Pankaj *1, Mandore Paresh1,
Patil Bharat1, Tekade B.W. 1,
Thakare V.M1,Dr. Patil V.R. 1
1T.V.E.Sís College of Pharmacy; Faizpur (M.S.), India
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