Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Milk thistle (Silybum marianum, family-Compositae) is widespread throughout the world. Milk thistle's common name comes from the white markings on the leaves and its milky white sap used traditionally by nursing mothers to increase milk. Milk thistle appears to be safe and have multiple health benefits on various liver conditions viz; liver cirrhosis, alcoholic hepatitis, alcoholic fatty liver, liver poisoning, and viral hepatitis. Primary chemical constituents of Milk Thistle include flavolignans (silymarin), tyramine, histamine, gamma linoleic acid, essential oil, mucilage, and bitter principle. Available evidence is not sufficient to suggest whether milk thistle may be more effective for some liver diseases than others or if effectiveness might be related to duration of therapy or chronicity and severity of liver disease.
Key words: Milk Thistle, Liver diseases, Liver poisoning, Silymarin, Tyramine, Hiatamine.
April 2011 Issue
April - 2011 / Volume - 3/Issue - 02
( Total Articles =26 )
Article No 01
April - 2011 / Volume - 3 / Issue - 02 / Article No - 01 / Review Article
MILK THISTLE (SILYBUM MARIANUM) : A REVIEW
Ajit Kiran Kaur*1,
A.K.Wahi 2, Brijesh kumar 1, Anil Bhandari 1,
1Deptt. of Pharmacy, Jodhpur National University, Jodhpur
2Gyani Inder Singh Institute of Professional Studies,
3Dr. K.N.Modi Institute of Pharmaceutical
Education and Research, Modinagar.
Ajit Kiran Kaur