Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Recent drug discovery using advanced techniques such as genomics, combinatorial chemistry, high throughput screening and in silico three dimensional drug design has yielded drug candidates with low water solubility and thus an inherently low mucosal permeability which makes the development of pharmaceutical formulations difficult. To overcome these, particulate systems like microparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamics properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Various polymers have been used in the formulation of microparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. The review embraces various aspects of microparticle formulations, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes.
Key words: microparticles, absorption, low solubility
March - 2011 / Volume - 3/Issue - 1
( Total Articles =25 )
March 2011 Issue
Article No 12
March - 2011 / Volume - 3 / Issue - 01 / Article No - 12 / Research Article
MICROPARTICLES: AN APPROACH FOR BETTERMENT OF DRUG DELIVERY SYSTEM
Abhay N. Padalkar1*, Sadhana R.Shahi1,
Mahesh W. Thube1
1Government College of Pharmacy,
Aurangabad-431005, M.S, India