Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
The challenge in drug targeting is not only the targeting of drug to a specific site but also retaining it for the desired duration to elicit pharmacological action. For a nanosystem administered intravenously, the first and foremost barrier is that of the vascular endothelium and the basement membrane. Also, plasma proteins have the \ability to affect the biodistribution of drug carrier systems introduced in the blood stream. The in vivo biodistribution and opsonization of nanosystems in blood circulation is governed by their size and surface characteristics. For the nanosystem to remain in blood circulation for a long time, the major problem is to avoid its opsonization and subsequent uptake by the phagocytic cells. The tight endothelial cells in brain constitute the blood brain barrier (BBB), which restricts the entry of most drugs and delivery systems. However vascular endothelium is not uniform throughout. Another barrier is that of the extracellular matrix, which should be crossed to access the target cells in a tissue. If the whole tissue constitutes a target then the uniform distribution of drug throughout the tissue is another problem.
Key words: BBB,Biodistribution,nanoparticals,brain,nanosystem,
March - 2011 / Volume - 3/Issue - 1
( Total Articles =25 )
March 2011 Issue
Article No 4
March - 2011 / Volume - 3 / Issue - 01 / Article No - 4 / Review Article
DRUG TARGETING TO BRAIN : A REVIEW
Daljeet Sharma1*, Narendra Nager1,
Ravindra Pal Sing1,Ashish Kumar Sharma1
1Department Of Pharmacy
Suresh Gyan Vihar University; Jaipur
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