Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
The present study was carried out to evaluate the antioxidant activities and total phenolic assay of Ocimum tenuiflorum. This was achieved by screening the leaf and stem extracts for their free radical scavenging properties using BHT (Butylated hydroxyl toluene) and ascorbic acid as standard antioxidant. Total phenolic content was estimated in both extracts, leaf extract showing more activity (3.66g/100gm) than stem. 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging activity was assayed, leaf showing 71% higher activity than stem, In leaf extract showing more (82%) of Superoxide anion scavenging activity than stem. Hydroxyl radical scavenging activity was assayed leaf showing 69.2% higher activity than stem. Determination of carotenoids shows 26.5g/100gm higher in leaf extract. Quantification of ascorbic acid shows higher in leaf extract 6.4g/100gm than stem. The present study reveals that O. tenuiflorum would exert several beneficial effects by virtue of their antioxidant activity and could be hardnosed as drug formulation.
Key words: Ocimum tenuiflorum, total phenols, antioxidant activity, free radical scavenger.
March - 2011 / Volume - 3/Issue - 1
( Total Articles =25 )
March 2011 Issue
Article No 2
March - 2011 / Volume - 3 / Issue - 01 / Article No -2 / Research Article
ANTIOXIDANT ACTIVITY OF METHANOL EXTRACT OF OCIMUM TENUIFLORUM (DRIED LEAF AND STEM)
Balaji R 1, Prakash G 1, Suganya devi P 1,
Dr. Aravinthan K M 1
1Dr.Mahalingam center for research & development,
Research Department of Biotechnology,
Pollachi-642001, Tamilnadu, India