ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
The aim of the present study was to prepare Simvastatin nanoparticles by nanoprecipitation method using a partially water-miscible solvents and the mutual saturation of the aqueous and organic phases prior to form a nanosuspention in order to reduce the initial thermodynamic instability of the nanoparticles. Because of the self-emulsifying properties of the methacrylic acid co-polymers, it was possible to prepare aqueous dispersions of colloidal size containing up to 30% w/v of Eudragit L100 using methanol as a water-miscible solvent with surfactant. Nanoparticles have become an important area of research in the field of drug delivery, because they have the ability to deliver a wide range of drugs to varying areas of the body for sustained periods of time. The nanoparticles have a higher surface-to-volume ratio as compared with bulk material, and therefore the dose and frequency of administration would be reduced hence increasing patient compliance.

Key words:
Nanoparticles, Nanoprecipitation techniques, Simvastatin.
Article No 23
February - 2011 / Volume - 2 / Issue - 12 / Article No - 23 / Research Article


PREPARATION AND OPTIMIZATION OF SIMVASTATIN NANOPARTICLE FOR SOLUBILITY ENHANCEMENT AND IN- VIVO STUDY

Mukesh S Patil*1
, Kedar R Bavaskar1,
Ghanashyam A Girnar2,
Dr. Ashish S Jain 1, Dr. Avinash R Tekade2.

1Department of Pharmaceutics
Gangamai Education Society College of Pharmacy,
Nagaon, Dhule. Maharshtra, India.
2Department of Pharmaceutics,
R.C.Patel College of Pharamacy Shirpur,
Dhule , Maharshtra, India.
Email:kedar.bavaskar@gmail.com
Mukesh Patil
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue
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