ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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ABSTRACT
  
Cystic fibrosis (CF) is an inherited disease of secretory glands.Cystic fibrosis mostly affects the lungs, pancreas, liver, intestines, sinuses, and sex organs. It doesn't affect the brain. A defect in the CFTR gene causes cystic fibrosis. This gene makes a protein that controls the movement of salt and water in and out of body's cells. Every person inherits two CFTR genes .one from each parent. Children who inherit a faulty gene from each parent will have cystic fibrosis. Diagnose  of cystic fibrosis are based on the results from various tests Newborn Screening, Sweat Test, Prenatal Screening, Cystic Fibrosis Carrier Testing, Other Tests. Cystic fibrosis  treatments have greatly improved in recent years. Treatments are based on various body part. In treatment of  Cystic fibrosis Chest Physical Therapy, Exercise Therapy, Medicines are used & mostly Anti-inflammatives, Antibiotics, Antihistamines, Mucolytics, Vitamins, GI drugs, Stool Softeners, Bronchodilators, Pancreatic Enzymes, Nasal Sprays are used.
As new treatments are developed for patients with CF, efforts should be made to balance treatment burden with quality of life.This review highlights emerging treatments, obstacles to optimizing outcomes, and key future directions for research.

Key words:
Cystic fibrosis, Mucoviscidosis, CFTR, Sweat Test, Chest Physical Therapy .
Ingle Vaibhav
Article No 21
February - 2011 / Volume - 2 / Issue - 12 / Article No - 21 / Review Article


RECENT TRENDS IN MANAGEMENT OF CYSTIC FIBROSIS:
A REVIEW


Ingale Vaibhav.B
1*,S.R.Butle


1Department Of Pharmaceuticalc Chemistry, 
School  Of  Pharmacy, S.R.T.M.University Nanded,
Email:vaibhav3ingale3@gmail.com
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue
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