ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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January - 2010 / Volume - 2/Issue - 11
( Total Articles =15 )
January 2011 Issue
ABSTRACT
  
InhA, the enoyl reductase from Mycobacterium tuberculosis and a member of the short-chain dehydrogenase/reductase (SDR) family, catalyzes the NADH-dependent reduction of long chain trans-2-enoyl-ACP fatty acids in the type II fatty acid biosynthesis pathway of M. tuberculosis. In the current study, we have generated shape and rocs based query for highly active compounds of INHA (oxopyrrolidine derivative), which is complexed with (PDB: 2H7M). Generated query was validated for goodness of hits and the predictive power of the query was determined. This query was further used for virtual screening. The top 10% screening hits were analyzed and docked. Based on the protein ligand interactions few final hits were selected for enzymatic screening studies.


Key words:
Inha reductase, Mycobacterium tuberculosis, Ligand-Based Virtual Screening

Article No 20
February - 2011 / Volume - 2 / Issue - 12 / Article No - 20 / Research Article


IDENTIFICATION OF NOVEL AND POTENT INHIBITORS AGAINST INHA REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS THROUGH A LIGAND-BASED VIRTUAL SCREENING APPROACH

Uday Chandra Kumar1*
, Shaik Mahmood1

1Bioinformatics Division,
Environmental Microbiology Lab,
Department of Botany,Osmania University,
Hyderabad 500 007, A.P., India.
Email:upendra613@gmail.com
Uday Chandra Kumar
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