Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Recently the squid pens, a rich source of ß - chitin contains low contents of inorganic compounds, have become available in considerable amounts as a refuse of the fishery industries in India. Thus, the aim of this work is to use squid pens from Doryteuthis sibogae, found in the Indian coast, squid pens were submitted usual sequence of treatment used for chitin extraction- demineralization and deproteinaization but due to its low content of inorganic compounds a two step alkaline treatments was enough to produce ß - chitin with low content of metals such as Mn (0.260ppm), Cu (0.905ppm), Mg (11.01ppm) and Ca (24ppm) reported. And the degree of acetylation was 45.12% in IR Spectrum and 043.47% in UV Spectrophotometer respectively. Regardless of the treatment employed for the extraction of the ß - chitin and chitosan from squid pens, its infra red spectra and UV spectrophotometer method showed only minor differences, however they were clearly distinguished from commercial a - chitin.
Key words: Squid pen, ß - chitin, chitosan, Degree of acetylation, FT IR, UV Spectrophotometer
Article No 19
February - 2011 / Volume - 2 / Issue - 12 / Article No - 19 / Research Article
PHYSICOCHEMICAL CHARACTERIZATION OF BIOPOLYMERS CHITIN AND CHITOSAN EXTRACTED FROM SQUID DORYTEUTHIS SIBOGAE ADAM, 1954 PEN
Barwin Vino A.1*, Ramasamy P1,
Vairamani S1,Shanmugam A1
1Centre of Advanced Study in Marine Biology
Faculty of Marine Sciences,Annamalai University
Barwin V. A.
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue