Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Pulmonary drug delivery system is a needle free technique. The origin of inhaled therapies seen in back 4000 years ago to India, where people smoked the leaves of the Atropa belladonna plant to suppress cough. In the 19th and early 20th centuries, asthmatics smoked asthma cigarettes that contained stramonium powder mixed with tobacco to treat the symptoms of their disease. Now a day’s pulmonary drug delivery remains the preferred route for administration of various drugs. It is an important research area which impacts the treatment of illnesses including asthma, chronic obstructive pulmonary disease and various diseases. Drug is delivered directly to the conducting zone of the lungs.
In this article, we summarize recent advances in applications of pulmonary drug delivery system. previously pulmonary drug delivery is used for management of Asthma and COPD only but due advancement in application nowadays Pulmonary drug delivery is useful to treat Diabetes, angina pectoris, cancer , bone disorders ,migraine,tuberculosis,acute lung injury and others. .
Key words: Asthma, pulmonary route, application, bone disorders, inhalation therapy.
Article No 18
February - 2011 / Volume - 2 / Issue - 12 / Article No - 18 / Review Article
RECENT TRENDS IN APPLICATIONS OF PULMONARY DRUG DELIVERY: A REVIEW
Siraj Shaikh*1 Syed Nazim1, Afsar Shaikh1 ,
Tarique Khan1, Md.Zameeruddin1,
Quazi Majaz1, Shailesh Chalikwar 2
1Ali-Allana college of pharmacy Akkalkuwa
Dist, Nandurbar, Maharashtra, India.
2R.C.Patel college of pharmacy,Shirpur
Dist Dhule, Maharashtra, India.
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue