ABSTRACT

   Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.



        

Key words:
Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
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January - 2010 / Volume - 2/Issue - 11
( Total Articles =15 )
January 2011 Issue
ABSTRACT
  
  
Progeria is a progressive disorder that causes children to age rapidly beginning in two years of life. The children with Progeria also known as Hutchinson - Gilfold Progeria Syndrome (HGPS) generally appear normal at birth. Progeria was first described in an academic journal by Dr. Jonathan Hutchinson in 1886, and Dr. Hastings Gilfold in 1897 - both in England. It is a rare disorder with a reported incidence of one in 8 millions births. It occurs sporadically and is believed to follow an autosomal recessive inheritance. Progeria signs include growth failure, loss of body fat and hair, aged - looking skin, stiffness of joints, hip dislocation, generalized atherosclerosis, cardiovascular disease and stroke. This review summarizes the clinical characteristics and the underlying mutation in the Lamin A gene, diagnostic methods and management and future directions of this disease.


Key words:
Progeria, Hutchinson - Gilfold Progeria Syndrome (HGPS), Lamin A gene mutation.

Article No 11
February - 2011 / Volume - 2 / Issue - 12 / Article No - 11 / Review Article

PROGERIA  - A PREMATURE AGING IN CHILDRENS (REVIEW)

N.B.Prabhavathi 1*,
J.Mastanaiah 2, M.V.Sunil kumar 3

1St.Annís college of pharmacy,Nayunipally,
Vetapalem -523187, A.P, India.
2SANA college of Pharmacy,
Kodad-508206, A.P, India.
3Trident Pharmaceuticals Pvt. Ltd.
Hyderabad,A.P, India.
Email:prabha.pharma3@gmail.com
N.B. Prabhavathi
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