Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
Among bacteria Streptomyces aureofaciens are the cost effective source of biomaterial for biosynthesis of silver nanoparticle. In this study, silver nanoparticles were synthesized extracellularly using Streptomyces aureofaciens and evaluated for its wound healing activity. Two models i.e. excision wound model and thermal wound model were used for this purpose. Its antimicrobial activity was also evaluated by disc diffusion method. In dose at 20mg of silver nanoparticle showed significant reduction in excision wound within 8 days. The results suggested that the silver nanoparticles synthesized from Streptomyces aureofaciens possess effective wound healing activity when compared with silver nitrate.
Key words: Silver Nanoparticle; Wound healing; Streptomyces; Antimicrobial.
Article No 10
February - 2011 / Volume - 2 / Issue - 12 / Article No - 10 / Research Article
ANTIMICROBIAL AND WOUND HEALING ACTIVITY OF SILVER NANOPARTICLES SYNTHESIZED FROM STREPTOMYCES AUREOFACIENS
Sundaramoorthi. C1*, Devarasu. S.,
Vengadesh prabhu. K
1Department of Pharmaceutical Biotechnology,
KMCH College of Pharmacy,Kalapatti Road,
Coimbatore-641 048,Tamil Nadu, India.
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue