Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
The objective of the present work was to evaluate the anthelmintic potency of roots extract of Tamarindus indica Linn by using different solvent systems (Methanol, Ethanol and Water) using Indian earth warm as test worm. The various concentration of different solvents extracts were tested in bioassay which involved determination of time of paralysis (p) and time of death (d) of the worm. Piperazine citrate (10 mg/ml) used as reference sample. The results of present study indicate that the crude aqueous extract significantly demonstrated paralysis and death of worms especially at higher concentration (160 mg/ml) compared with reference drug sample of piperazine citrate. We concluded that the use of the roots aqueous extract of Tamarindus indica Linn has been confirmed Anthelmintic potency and further studies are suggested to isolate the active principles responsible for the activity.
Key words: Tamarindus indica root, Anthelmintic activity, Piperazine citrate, Tween 80, Different solvent extracts (Methanol, Ethanol, Water)
Article No 9
February - 2011 / Volume - 2 / Issue - 12 / Article No - 9 /Research Article
STUDIES ON ANTHELMINTIC ACTIVITY OF ROOTS EXTRACT OF TAMARINDUS INDICA LINN BY USING DIFFERENT SOLVENT SYSTEMS
K. Mallikarjuna Rao*1, M. Gobinath1,
M.William Carey2, Ch.Praveen Kumar1,
1Ratnam Institute of Pharmacy, Pidathapolur,
Nellore - 524 346, Andhra Pradesh, India
2Department of Pharmaceutical Sciences,
S.G.P.R. Govt Polytechnic, Thandrapadu, Kurnool.
Andhra Pradesh, India
K. Mallikarjuna Rao
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue