Typhoid fever (TF) is an acute systemic infection caused by Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B. It is transmitted by the fecal oral route mainly via contaminated food and water. The developing countries have high rate of morbidity and mortality due to Typhoid fever, epidemics take place in developed world also. There are increased incidences of multi drug resistant in S. typhi strains that has further complicated its management and only a few antibiotics are now effective in treatment of typhoid. We report that the aqueous extracts of fruit peel Citrus sinensis (L.) confer anti typhoid activity against Salmonella Typhi, Salmonella Para Typhi A and Salmonella Para Typhi B respectively on comparison with ciprofloxacin.
Key words: Typhoid fever, Salmonella Typhi, Salmonella Para Typhi A , Salmonella Para Typhi B, anti typhoid activity, Citrus sinensis.
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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND DEVELOPMENT
In the present research work there are synthesis some quinoline derivations by using microwave techniques. The synthesis of 6- methoxy acetanilide (1) by reaction of 6-methoxy aniline with acetic anhydride under microwave irradiation. This acetanilide (2) treated withPOCl3 and DMF under microwave irradiation to form 2-chloro -3- formyl-6- methoxy quinoline (3). the synthesis of 2- chloro-6-methoxy 3- substituted amine by condensing with 2-chloro -3- formyl-6- methoxy quinoline(3) and substituted aromatic amine in presence of catalytic amount of glacial acetic acid under microwave irradiation and get final products(4) which displays valuable pharmaceutical activities such as antifungal, antibacterial, anticancer and anti inflammatory activities. The structural characterization of the synthesized compound by I R. and 1HNMR spectral data reported in table No 1.
The synthesized quinoline derivatives were tested their antimicrobial activity with different strain of gram-positive and gram- negative bacteria and fungi the chloro and bromo moiety derivatives of the synthesized compounds show good activity against S-aurous and B-subtilis and nitro group containing compounds showed moderate activity against gram- negative stain of micro organisms.
Key words: Quinoline, substituted amines, microwave techniques, aromatic amin
Article No 7
February - 2011 / Volume - 2 / Issue - 12 / Article No - 7 / Research Article
A MICROWAVE SYNTHESIS AND CHARACTERIZATION OF SOME QUINOLINE DERIVATIVES AND TESTED THEIR ANTIMICROBIAL ACTIVITY
Ajaypal Prajapati1 *, O.P. Chourasia1
1Dept. of chemistry Dr. H S Gour University
Sagar M.P. INDIA
February - 2011 / Volume - 2/Issue - 12
( Total Articles =25 )
February 2011 Issue